The EPITRAN Action will be implemented through 5 Working Groups (WGs), 4 of which focus on the different approaches to developing epitranscriptomics research and on promoting its links with medicine and business. While WG1 and WG3 will assess and explore the mechanisms of epitranscriptomics and their role in disease onset and progression, WG2 will provide a core computational and methodological layer for hypothesis generation, data analysis streamlining and analytical protocols. WG4 tackles the translation of knowledge to industrial application in biomarker and drug development through active dissemination and exploitation actions. A fifth, transversal WG5 will provide extensive training opportunities and tools to the Action participants. The objectives and tasks of each working group combine the various skills and expertises of the participants, by maximizing the coherence of each group while promoting interdisciplinarity through the tight connections between them.