KEYWORDS
ageing
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mouse models
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Caenorhabditis elegans
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specialized ribosomes
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cellular senescence
Markus Schosserer is postdoc/lecturer at University of Natural Resources and Life Sciences, Vienna, Department of Biotechnology, Vienna, Austria since 2012. He received his PhD in Biotechnology from the same university in 2012.
His research interests lie in the areas of Biogerontology and RNA biology, with special emphasis on RNA modifications, ribosomes, cellular senescence and Caenorhabditis elegans. Markus Schosserer is also interested in advanced microscopy techniques, including Raman and STED. His teaching activities include courses on Biology of Aging, Animal Cell Culture, Microscopy and Flow Cytometry.
Markus Schosserer co-authored 22 papers (November 2018) and presented his work at several national in international conferences. He won four poster prizes, two best talk awards and collaborates actively with researchers in several other disciplines of ageing research and RNA/ribosome biology.
model systems:
mammalian cells
Caenorhabditis elegans
transgenic mice
RNA/ribosome biology:
bisulfite sequencing/COBRA
measurement of bulk protein synthesis by OPP incorporation
translational fidelity assays
ageing research:
lifespan (yeast, C. elegans, D. melanogaster, mice)
healthspan phenotyping of C. elegans (locomotion, electrophysiology of the pharynx, memory function, stress resistance)
healthspan phenotyping of mice (frailty index, memory function)
cellular senescence (serial passaging, SIPS), confirmation of senescent phenotype (SA-beta-Gal, BrdU-assay, morphology, SASP, apoptosis)
microscopy:
life cell imaging
Raman microspectroscopy
gSTED super-resolution microscopy
Schosserer, M; Minois, N; Angerer, TB; Amring, M; Dellago, H; Harreither, E; Calle-Perez, A; Pircher, A; Gerstl, MP; Pfeifenberger, S; Brandl, C; Mohr, T; Sonntagbauer, M; Kriegner, A; Linder, A; Weinhäusel, A; Steiger, M; Mattanovich, D; Rinnerthaler, M; Karl, T; Sharma, S; Entian, KD; Kos, M; Breitenbach, M; Wilson, IBH; Polacek, N; Grillari-Voglauer, R; Breitenbach-Koller, L; Grillari, J (2015): Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. Nature Communications 2015; 6/6158
Nagelreiter, F; Coats, MT; Klanert, G; Gludovacz, E; Borth, N; Grillari, J; Schosserer, M (2018): OPP Labeling Enables Total Protein Synthesis Quantification in CHO Production Cell Lines at the Single-Cell Level. Biotechnol J. 2018; Apr;13(4):e1700492
Schosserer, M; Grillari, J; Breitenbach, M (2017): The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy. Front Oncol. 2017; 7:278
Schosserer, M; Banks, G; Dogan, S; Dungel, P; Fernandes, A; Presen, DM; Matheu, A; Osuchowski, M; Potter, P; Sanfeliu, C; Tuna, BG; Varela-Nieto, I; Bellantuono, I (2018): Modelling physical resilience in ageing mice. Mech Ageing Dev. 2018
Garschall, K; Dellago, H; Gáliková, M; Schosserer, M; Flatt, T; Grillari, J (2017): Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span. npg Aging and Mechanisms of Disease 2017; 3(5)
Khan, A; Dellago, H; Terlecki-Zaniewicz, L; Karbiener, M; Weilner, S; Hildner, F; Steininger, V; Gabriel, C; Mück, C; Jansen-Dürr, P; Hacobian, A; Scheideler, M; Grillari-Voglauer, R; Schosserer, M; Grillari, J (2017): SNEV(hPrp19/hPso4) Regulates Adipogenesis of Human Adipose Stromal Cells. Stem Cell Reports 2017; 8(1):21-29
