KEYWORDS
RNA modifications
•
(cytosine-5) methylation
•
tRNA fragments
•
stress response
Scientific Education & Career History
Since 2017 Associate Professor, Medical University of Vienna
2015 – 2017 Assistant Professor, Medical University of Vienna
2014 – 2015 Group Leader, MFPL, University of Vienna
2014 Habilitation, “Venia docendi” in Biochemistry, University of Heidelberg, Germany
2008 – 2014 Project Leader at German Cancer Research Center (F. Lyko), Heidelberg, Germany (F. Lyko)
2004 – 2008 Postdoctoral Fellow at German Cancer Research Center (F. Lyko), Heidelberg, Germany
2002 – 2004 Postdoctoral Fellow, Karolinska Institutet, Medical Nobel Institute (J. Frisén), Stockholm, Schweden
2002 PhD in Biochemistry, Institute of Molecular Pathology (IMP) (J.A. Knoblich), Vienna, Austria
1998 PhD Studies, Albert-Einstein College of Medicine (R.H. Singer), New York, USA
1996 Diploma Thesis, Rockefeller University (T. de Lange), New York, USA
1996 Diploma Studies at Freie Universität Berlin, Berlin, Germany
Biochemistry,
nucleic acid chemistry,
asymmetric cell divisions,
stem cell biology,
RNA bisulfite sequencing,
Drosophila genetics,
mammalian brain development
List of the 10 Most Important Peer-reviewed Publications
Genenncher, B., Durdevic, Z., Hanna, K., Zinkl, D., Mobin, M.B., Senturk, N., Da Silva, B., Legrand, C., Carré, C., Lyko, F. & Schaefer, M. (2018). Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats. Cell Rep. 22 (7): 1861–74.
Durdevic, Z., Mobin, M.B., Hanna, K., Lyko, F. and Schaefer, M. (2013). The RNA methyltransferase Dnmt2 is required for efficient Dicer-2 dependent siRNA pathway activity in Drosophila. Cell Rep. 4 (5): 931-937.
Durdevic, Z., Hanna, K., Gold, B., Pollex, T., Cherry, S., Lyko, F., and Schaefer, M. (2013). Efficient RNA virus control in Drosophila requires the RNA methyltransferase Dnmt2. EMBO Rep. 14 (3): 269-275.
Raddatz, G., Guzzardo, P.M., Olova, N., Fantappié, M.R., Rampp, M., Schaefer, M., Reik, W., Hannon, G.J., and Lyko, F. (2013). Dnmt2-dependent methylomes lack defined DNA methylation patterns. Proc Natl Acad Sci USA. 110 (21): 8627-8631.
Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M., and Lyko, F. (2010). RNA methylation by the DNA methyltransferase homologue Dnmt2 protects transfer RNAs against stress-induced cleavage. Genes Dev. 24 (15): 1590-1595.
Schaefer, M., Pollex, T., Hanna, K. and Lyko, F. (2009). RNA cytosine methylation analysis by bisulfite sequencing. Nucleic Acids Res. 37 (2): e12.
Schaefer, M. and Lyko, F. (2010). Lack of evidence for DNA methylation of Invader4 retroelements in Drosophila and implications for Dnmt2-mediated epigenetic regulation. Nat Genet. 42 (11): 920-921.
Schaefer, M., Petronczki, M., Dorner, D., Forte, M. and Knoblich, J.A. (2001). Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system. Cell. 107 (2): 183-194.
Schober, M., Schaefer, M. and Knoblich, J.A. (1999). Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts. Nature. 402 (6761): 548-551.
Bertrand, E., Chartrand, P., Schaefer, M., Shenoy, S.M., Singer, R.H. and Long, R.M. (1998). Localization of ASH1 mRNA particles in living yeast. Mol. Cell. 2 (4): 437-445.
