KEYWORDS

RNA modifications

(cytosine-5) methylation

tRNA fragments

stress response

BIO

Scientific Education & Career History    

Since 2017            Associate Professor, Medical University of Vienna

2015 – 2017           Assistant Professor, Medical University of Vienna

2014 – 2015           Group Leader, MFPL, University of Vienna

2014                       Habilitation, “Venia docendi” in Biochemistry, University of Heidelberg, Germany

2008 – 2014           Project Leader at German Cancer Research Center (F. Lyko), Heidelberg, Germany (F. Lyko)

2004 – 2008           Postdoctoral Fellow at German Cancer Research Center (F. Lyko), Heidelberg, Germany 

2002 – 2004           Postdoctoral Fellow, Karolinska Institutet, Medical Nobel Institute (J. Frisén), Stockholm, Schweden 

2002                       PhD in Biochemistry, Institute of Molecular Pathology (IMP) (J.A. Knoblich), Vienna, Austria 

1998                       PhD Studies, Albert-Einstein College of Medicine (R.H. Singer), New York, USA 

1996                       Diploma Thesis, Rockefeller University (T. de Lange), New York, USA 

1996                       Diploma Studies at Freie Universität Berlin, Berlin, Germany

KNOW-HOW

Biochemistry,

nucleic acid chemistry,

asymmetric cell divisions,

stem cell biology,

RNA bisulfite sequencing,

Drosophila genetics,

mammalian brain development

KEY PUBLICATIONS

List of the 10 Most Important Peer-reviewed Publications

Genenncher, B., Durdevic, Z., Hanna, K., Zinkl, D., Mobin, M.B., Senturk, N., Da Silva, B., Legrand, C., Carré, C., Lyko, F. & Schaefer, M. (2018). Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats. Cell Rep. 22 (7): 1861–74. 

Durdevic, Z., Mobin, M.B., Hanna, K., Lyko, F. and Schaefer, M. (2013). The RNA methyltransferase Dnmt2 is required for efficient Dicer-2 dependent siRNA pathway activity in Drosophila. Cell Rep. 4 (5): 931-937.

Durdevic, Z., Hanna, K., Gold, B., Pollex, T., Cherry, S., Lyko, F., and Schaefer, M. (2013). Efficient RNA virus control in Drosophila requires the RNA methyltransferase Dnmt2. EMBO Rep. 14 (3): 269-275.

Raddatz, G., Guzzardo, P.M., Olova, N., Fantappié, M.R., Rampp, M., Schaefer, M., Reik, W., Hannon, G.J., and Lyko, F. (2013). Dnmt2-dependent methylomes lack defined DNA methylation patterns. Proc Natl Acad Sci USA. 110 (21): 8627-8631.

Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M., and Lyko, F. (2010). RNA methylation by the DNA methyltransferase homologue Dnmt2 protects transfer RNAs against stress-induced cleavage. Genes Dev. 24 (15): 1590-1595.

Schaefer, M., Pollex, T., Hanna, K. and Lyko, F. (2009). RNA cytosine methylation analysis by bisulfite sequencing. Nucleic Acids Res. 37 (2): e12.

Schaefer, M. and Lyko, F. (2010). Lack of evidence for DNA methylation of Invader4 retroelements in Drosophila and implications for Dnmt2-mediated epigenetic regulation. Nat Genet. 42 (11): 920-921.

Schaefer, M., Petronczki, M., Dorner, D., Forte, M. and Knoblich, J.A. (2001). Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system. Cell. 107 (2): 183-194.

Schober, M., Schaefer, M. and Knoblich, J.A. (1999). Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts. Nature. 402 (6761): 548-551.

Bertrand, E., Chartrand, P., Schaefer, M., Shenoy, S.M., Singer, R.H. and Long, R.M. (1998). Localization of ASH1 mRNA particles in living yeast. Mol. Cell. 2 (4): 437-445.

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