RNA modifications

(cytosine-5) methylation

tRNA fragments

stress response


Scientific Education & Career History    

Since 2017            Associate Professor, Medical University of Vienna

2015 – 2017           Assistant Professor, Medical University of Vienna

2014 – 2015           Group Leader, MFPL, University of Vienna

2014                       Habilitation, “Venia docendi” in Biochemistry, University of Heidelberg, Germany

2008 – 2014           Project Leader at German Cancer Research Center (F. Lyko), Heidelberg, Germany (F. Lyko)

2004 – 2008           Postdoctoral Fellow at German Cancer Research Center (F. Lyko), Heidelberg, Germany 

2002 – 2004           Postdoctoral Fellow, Karolinska Institutet, Medical Nobel Institute (J. Frisén), Stockholm, Schweden 

2002                       PhD in Biochemistry, Institute of Molecular Pathology (IMP) (J.A. Knoblich), Vienna, Austria 

1998                       PhD Studies, Albert-Einstein College of Medicine (R.H. Singer), New York, USA 

1996                       Diploma Thesis, Rockefeller University (T. de Lange), New York, USA 

1996                       Diploma Studies at Freie Universität Berlin, Berlin, Germany



nucleic acid chemistry,

asymmetric cell divisions,

stem cell biology,

RNA bisulfite sequencing,

Drosophila genetics,

mammalian brain development


List of the 10 Most Important Peer-reviewed Publications

Genenncher, B., Durdevic, Z., Hanna, K., Zinkl, D., Mobin, M.B., Senturk, N., Da Silva, B., Legrand, C., Carré, C., Lyko, F. & Schaefer, M. (2018). Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats. Cell Rep. 22 (7): 1861–74. 

Durdevic, Z., Mobin, M.B., Hanna, K., Lyko, F. and Schaefer, M. (2013). The RNA methyltransferase Dnmt2 is required for efficient Dicer-2 dependent siRNA pathway activity in Drosophila. Cell Rep. 4 (5): 931-937.

Durdevic, Z., Hanna, K., Gold, B., Pollex, T., Cherry, S., Lyko, F., and Schaefer, M. (2013). Efficient RNA virus control in Drosophila requires the RNA methyltransferase Dnmt2. EMBO Rep. 14 (3): 269-275.

Raddatz, G., Guzzardo, P.M., Olova, N., Fantappié, M.R., Rampp, M., Schaefer, M., Reik, W., Hannon, G.J., and Lyko, F. (2013). Dnmt2-dependent methylomes lack defined DNA methylation patterns. Proc Natl Acad Sci USA. 110 (21): 8627-8631.

Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M., and Lyko, F. (2010). RNA methylation by the DNA methyltransferase homologue Dnmt2 protects transfer RNAs against stress-induced cleavage. Genes Dev. 24 (15): 1590-1595.

Schaefer, M., Pollex, T., Hanna, K. and Lyko, F. (2009). RNA cytosine methylation analysis by bisulfite sequencing. Nucleic Acids Res. 37 (2): e12.

Schaefer, M. and Lyko, F. (2010). Lack of evidence for DNA methylation of Invader4 retroelements in Drosophila and implications for Dnmt2-mediated epigenetic regulation. Nat Genet. 42 (11): 920-921.

Schaefer, M., Petronczki, M., Dorner, D., Forte, M. and Knoblich, J.A. (2001). Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system. Cell. 107 (2): 183-194.

Schober, M., Schaefer, M. and Knoblich, J.A. (1999). Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts. Nature. 402 (6761): 548-551.

Bertrand, E., Chartrand, P., Schaefer, M., Shenoy, S.M., Singer, R.H. and Long, R.M. (1998). Localization of ASH1 mRNA particles in living yeast. Mol. Cell. 2 (4): 437-445.