KEYWORDS
NUCLEAR RECEPTORS
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OBESITY
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DIABETES
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CANCER COLORECTAL
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DNA METHYLATION
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VITAMIN D
EDUCATION
1998 PhD in Biochemistry and Molecular Biology Medicine Faculty, Department of Neurophysiology, University of Granada, Spain. 2011 Executive Master for Technological and Innovative Entrepreneurs. Higher School of Business Studies. University and Assimilated Centres and Structures, Malaga, Spain.
CURRENT POSITION(S)
2014 – Researcher Associated to the Clinical Management Unit of Endocrinology and Nutrition, in the University Hospital Virgen de la Victoria, Biomedical Research Institute of Malaga, Spain. 2017 – Co-Researcher responsible and foundermember of the Biomedical Network Research Centre in Physiopathology of Obesity and Nutrition (CiberObn) Name of Faculty/ Department, Name of University/ Institution/ Country
PREVIOUS POSITIONS
2011 – 2014 Researcher contract stabilization in the Health Institute Carlos III, IMABIS Foundation, Malaga Spain 2005 – 2011 Leading Researcher contract Miguel Servet, Health Institute Carlo III, FIMABIS Foundation, Malaga Spain 2003 – 2005 Senior Researcher contract, Carlos Haya Foundation, Malaga Spain 2001 – 2003 Senior Researcher contract, Department of Biochemistry and Molecular Biology,University of Kuopio Finland 1999 – 2001 Postdoctoral contract in the Institute of Physiology-Chemistry in the University HenrichHein University, Dusseldorf, Germany
SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS More than 8 theses directed in the Science Area: Biomedicine, Endocrinology and Pharmacology.
TEACHING ACTIVITIES (if applicable) 2016 – 2018 Training of European technicians in New Methods in the Laboratory IBIMA University Málaga, Spain 2017 – 2018 Training of Medicine Students in Translational Science Seminars, Medicine Faculty, University of Malaga, Spain 2014 – 2017 Professor doctorate courses, Surgery and Nutrition Programme of the Medicine Faculty, Univ. Málaga, Spain 2010 – 2014 Teacher of Spanish higher education technicians, Technology Scientific Business in Málaga, Spain
ORGANISATION OF SCIENTIFIC MEETINGS (if applicable) 2018 Organizing Member of the V Meeting TARRACO-MALACA, Obesity and Diabetes, Tarragona Spain 2017 III Organizing Member of the Update Meeting Neurocognition, subprogram Obesity and Cancer, CiberObn, Malaga Spain 2016 III Meeting TARRACO-MALACA Obesity and Diabetes, Malaga, Spain This proposal version was submitted by Elena MARTIN on 29/08/2018 16:05:47 Brussels Local Time. Issued by the Participant Portal Submission Service. Macías-González, M. Part B1 EpiOncObesity 2015 I Organizing Member of the Update Meeting Neurocognition, subprogram Obesity and Cancer, CiberObn, Malaga Spain
INSTITUTIONAL RESPONSIBILITIES (if applicable) 2015-2018 International Expert in the: Competence Programme to the Technology Agency of the Czech Republic Research Activities for the seventh framework programme (FP7) in the EU 2011-2015 External Expert of the European Union –funding Health Research Project (Nº Ref: EX2006C097614), 2011-2013 2008-2018 National Expert of the National Government in Health in Biomedicine, Cardiovascular disease, obesity and diabetes type 2
MEMBERSHIPS OF SCIENTIFIC SOCIETIES (if applicable) 2015-2019 Member of working group of the Collaborating Centres for Obesity Management (COMs) for the European Association of the Study in Obesity (EASO) 2014 –2018 Member of the Spanish Society in Biochemistry and Molecular Biology (SEBBM) and Spanish Society in Endocrinology (SEEN), and Obesity Spanish Society (SEDO) 2007-2019 Member of the Network Center in Physiopathology of the Obesity and Nutrition, ISCIII, Science Government, Spain
Articles (2008-2018) Total number of original articles, bibliographical reviews, editions and scientific reports: 65 Total number of times cited since 2008 more than 1500 3439 H-index (2018): 31 Average Impact Factor: 4,258
Industrial and Intelectual Property in the last 7 years Title registered industrial property: Precision medicine aimed at the diagnosis, prognosis and prediction of colorectal cancer Inventors/authors/obtainers: Felipe casanueva; Ana Belen Crujeiras; manuel macias gonzalez; Francisco Jose Tinahones Entity holder of rights: IBIMA, This proposal version was submitted by Elena MARTIN on 29/08/2018 16:05:47 Brussels Local Time. Issued by the Participant Portal Submission Service. Macías-González, M. Part B1 EpiOncObesity CIBERobn, SAS, USC Nº of application: P201731237 Country of inscription: Spain Date of register: 01/06/2017 Title registered industrial property: Method to detect and quantify DNA methylations Type of industrial property: Patent of invention Inventors/authors/obtainers: MANUEL MACIAS GONZALEZ; HATIM BOUGHANEM Entity holder of rights: SAS Nº of application: P201731370 Country of inscription: Spain 20/10/2017 Title registered industrial property: OXAZOLIDINONE DERIVATIVES AS PPARs LIGANDS. Inventors/authors/obtainers: MIGUEL ROMERO CUEVAS; FRANCISCO JAVIER PAVON MORON; FERNANDO RODRIGUEZ DE FONSECA; ANA BELEN TORRES ZAGUIRRE; PILAR GOYA LAZA; JOSE ELGUERO BERTOLINI; MARIA NIEVES FRESNO LOPEZ; RUTH PEREZ FERNANDEZ; MANUEL MACIAS GONZALEZ Entity holder of rights: FUNDACION IMABIS, CSIC-MADRID, SAS Reference/registry code: PCT/ES2014/070572. Nº of application: WO 2015/004306 A1 Country of inscription: Spain (P201331058) Date of register: 01/11/2014. EU patent: Yes International non-EU patent: Yes PCT patent: Yes Licences: Yes Operating aut.region/region: China / Saudi Arabia / United Arab Emirates / Ukraine / United States of America Invited presentations to peer-reviewed, internationally established conferences and/or international advanced schools 1.- First International Conference on Sun Exposure and Human Healthcare May 2019 in Baltimore 2.- Metabolic Reprogramming as a target for cancer and other diseases Workshop 2018, titled: Precision medicine addressed to the diagnosis, prognosis and prediction of the colorectal cancer associated with obesity 3.- Expert Referee Project in FONCYT, MINISTERIO DE CIENCIA TECNOLOGIA E INNOVACION PRODUCTIVA, Argentina 01/01/2018 – 31/12/2019 4.- Expert Referee Spanish Health Project Programmes from 2014-2018 5.- International Expert BIOCEV: Biotechnology and biomedicine center of the academy of sciences. Affiliation entity: Univ VESTEC 01/06/2015 – 31/12/2016 6 Committee title: International Expert in the: Competence Programme to the Technology Agency of the Czech Republic Research Activities Affiliation entity: International Expert in the: Competence Programme to the Technology Agency of the Czech RepubliC 02/02/2011 – 31/12/2014 Organisation of International conferences in the field of the applicant − EPIONCOBESITY: búsqueda de nuevos biomarcadores en la prevención del cáncer. Type of activity: DIFUSION DE LAS TECNOLOGIAS a través de una plataforma ROCHE ha puesto marcha ZINKINN (https://www.zinkinn.es/epioncobesity) Geographical area: European Union Convening entity: ROCHE DIAGNOSTIC − Meeting TARRACO-MALACA Type of activity: COMITE ORGANIZADOR Y SPEAKER Geographical area: National City of event: TARRAGONA, Catalonia, Spain Convening entity: CiberObn y Ciberdem e IBIMA Type of entity: Public Research Body City convening entity: TARRAGONA, Catalonia-Malaga, Spain Type of participation: Organiser from 2015 to 3028 − NOCHE EUROPEA DE INVESTIGADORES Type of activity: DIFUSION A NIVEL SOCIAL DE LA INVESTIGACION Geographical area: National Convening entity: Comisión Europea a través de Horizonte 2020 City convening entity: MALAGA, Andalusia, Spain Start-End date: 29/09/2015- 23/09/2017 − COST Action FA 1403 Interindividual variation in response to consumption of plant food bioactives and determinants involved (POSITIVe) Type of activity: PARTICIPANT Minutes of WG2 meeting Geographical area: European Union Convening entity: European Cooperation in Science and Technology Type of entity: Associations and Groups City convening entity: BUCAREST, Romania Start-End date: 15/03/2016 – 17/03/2016 − XII CONGRESO DE LA SOCIEDAD ESPAÑOLA DE LA OBESIDAD Type of activity: COMITE ORGANIZADOR Geographical area: National City of event: MALAGA, Andalusia, Spain Convening entity: SEEDO Type of entity: Associations and Groups City convening entity: MALAGA, Andalusia, Spain Type of participation: Organiser Start-End date: 25/11/2015 – 27/11/2015 Duration: 2 days
1: Macías-González M, Martín-Núñez GM, Garrido-Sánchez L, García-Fuentes E, Tinahones FJ, Morcillo S. Decreased blood pressure is related to changes in NF-kB promoter methylation levels after bariatric surgery. Surg Obes Relat Dis. 2018 Sep;14(9):1327-1334. doi: 10.1016/j.soard.2018.06.011. Epub 2018 Jun 23. PubMed PMID: 30057095.
2: Castellano-Castillo D, Morcillo S, Clemente-Postigo M, Crujeiras AB, Fernandez-García JC, Torres E, Tinahones FJ, Macias-Gonzalez M. Adipose tissue inflammation and VDR expression and methylation in colorectal cancer. Clin Epigenetics. 2018 Apr 25;10:60. doi: 10.1186/s13148-018-0493-0. eCollection 2018. PubMed PMID: 29719581; PubMed Central PMCID: PMC5921388.
3: Crujeiras AB, Morcillo S, Diaz-Lagares A, Sandoval J, Castellano-Castillo D, Torres E, Hervas D, Moran S, Esteller M, Macias-Gonzalez M, Casanueva FF, Tinahones FJ. Identification of an episignature of human colorectal cancer associated with obesity by genome-wide DNA methylation analysis. Int J Obes (Lond). 2019 Jan;43(1):176-188. doi: 10.1038/s41366-018-0065-6. Epub 2018 May 1. PubMed PMID: 29717273.
4.- Jantsch MF(1), Quattrone A(2), O’Connell M(3), Helm M(4), Frye M(5), Macias-Gonzales M(6) et als. Positioning Europe for the EPITRANSCRIPTOMICS challenge. RNA Biol. 2018;15(6):829-831. doi: 10.1080/15476286.2018.1460996. Epub 2018 May
5.- Moreno Santos I, Castellano Castillo D, Lara MF, Fernández García JC, Tinahones FJ, Macías González M. IGFBP-3 interact with the vitamin D receptor in insulin signaling associated with obesity in visceral adipose tissue Int J Mol Sci 2017 Nov 7;18(11). IF:3,226 2º cuartil. PMID: 29112142
6.- Morcillo S, Macías González M, Tinahones FJ The effect of metabolic and bariatric surgery on DNA methylation patterns Curr Atheroscler Rep 2017 Aug 30;19(10):40 IF: 2.731 3º cuartil PMID: 28853041
7.- Crujeiras AB, Gómez Arbelaez D, Zulet MA, Carreira MC, Sajoux I, de Luis D, Castro AI, Baltar J, Baamonde I, Sueiro A, Macías González M, Bellido D, Tinahones FJ, Martínez JA, Casanueva FF. Plasma FGF21 levels in obese patients undergoing energy-restricted diet of bariatric surgery: a marker of metabolic stress? Int J Obes (Lond) 2017 Oct;41(10):1570-1578 IF: 5.337 1º cuartil-1º decil PMID: 28588304
8.- Crujeiras AB, Díaz Lagares A, Stefansson OA, Macías M, Sandoval J, Cueva J, López López R, Moran S, Jonasson JG, Tryggvadottir L, Olafsdottir E, Tinahones FJ, Carreira MC, Casanueva FF, Esteller M. Obesity and menopause modify the epigenomic profile of breast cancer. Endocr Relat Cancer 2017 Jul;24(7):351-363. IF: 5.267 1º cuartil PMID: 28442560
9.- Bandera Merchan B, Morcillo S, Martin-Nuñez G, Tinahones FJ, Macías-González M. The role of vita min D and VDR in carcinogenesis: Through epidemiology and basic sciences J teroid Biochem Mol Biol. 2017 Mar;167:203-218 IF: 3.985 1º cuartil PMID: 27913313
10.- Clemente-Postigo M, Muñoz-Garach A, Serrano M, Garrido-Sánchez L, Bernal-López MR, Fernández-García D, Moreno-Santos I, Garriga N, Castellano-Castillo D, Camargo A, Fernández-Real JM, Cardona F, Tinahones FJ, Macías-González M. Serum 25-hydroxyvitamin D and adipose tissue vitamin D receptor gene expression: relationship with obesity and type 2 diabetes. J Clin Endocrinol Metab. 2015. 1º cuartil
11.- Moreno-Santos I, Pavón FJ, Romero-Cuevas M, Serrano A, Cano C, Suardíaz M, Decara J, Suarez J, de Fonseca FR, Macías-González M. Computational and biological evaluation of N-octadecyl-N’-propylsulfamide, a selective PPARα agonist structurally related to N-acylethanolamines. PLoS One. 2014;9(3):e92195. IF: 3.730 1º cuartil-2º decil PMID: 24651609
