KEYWORDS

BIO

https://www.researchgate.net/profile/Mark_Helm/contributions?ev=prf_act

KNOW-HOW

LC-MS of RNA modifications

RNA seq based detection of RNA modifications

Bioconjugate Chemistry

KEY PUBLICATIONS

Double methylation of tRNA-U54 to 2′-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7.

Keller P, Freund I, Marchand V, Bec G, Huang R, Motorin Y, Eigenbrod T, Dalpke A, Helm M.

Nucleic Acids Res. 2018 Aug 8. doi: 10.1093/nar/gky644.

A Vastly Increased Chemical Variety of RNA Modifications Containing a Thioacetal Structure.

Dal Magro C, Keller P, Kotter A, Werner S, Duarte V, Marchand V, Ignarski M, Freiwald A, Müller RU, Dieterich C, Motorin Y, Butter F, Atta M, Helm M.

Angew Chem Int Ed Engl. 2018 Jun 25;57(26):7893-7897. doi: 10.1002/anie.201713188.

Detecting RNA modifications in the epitranscriptome: predict and validate.

Helm M, Motorin Y.

Nat Rev Genet. 2017 May;18(5):275-291. doi: 10.1038/nrg.2016.169.

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