Helm, Mainz, Germany

NAME
Mark Helm
PRIMARY AFFILIATION
Johannes Gutenberg-University Mainz
SECONDARY AFFILIATION
DEPARTMENT #1
Institute of Pharmacy and Biochemistry
DEPARTMENT #2
DEPARTMENT #3
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WEBSITE #3
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49-6131-3925731
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KEYWORDS

BIO

Click here to see Mark Helm profile on ResearchGate

KNOW-HOW

LC-MS of RNA modifications

RNA seq based detection of RNA modifications

Bioconjugate Chemistry

KEY PUBLICATIONS

Absolute quantification of noncoding RNA by microscale thermophoresis.

Jacob D, Thüring K, Galliot A, Marchand V, Galvanin A, Ciftci A, Scharmann K, Stock M, Roignant JY, Leidel SA, Motorin Y, Schaffrath R, Klassen R, Helm M.

Angew Chem Int Ed Engl. 2019 Mar 20. doi: 10.1002/anie.201814377.

Double methylation of tRNA-U54 to 2′-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7.

Keller P, Freund I, Marchand V, Bec G, Huang R, Motorin Y, Eigenbrod T, Dalpke A, Helm M.

Nucleic Acids Res. 2018 Aug 8. doi: 10.1093/nar/gky644.

A Vastly Increased Chemical Variety of RNA Modifications Containing a Thioacetal Structure.

Dal Magro C, Keller P, Kotter A, Werner S, Duarte V, Marchand V, Ignarski M, Freiwald A, Müller RU, Dieterich C, Motorin Y, Butter F, Atta M, Helm M.

Angew Chem Int Ed Engl. 2018 Jun 25;57(26):7893-7897. doi: 10.1002/anie.201713188.

Detecting RNA modifications in the epitranscriptome: predict and validate.

Helm M, Motorin Y.

Nat Rev Genet. 2017 May;18(5):275-291. doi: 10.1038/nrg.2016.169.

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