KEYWORDS

Embryonic stem cells

Epigenetics

Epitranscriptomics

Endogenous Retrovirus

Ageing

BIO

Diana holds a BS degree in Biochemistry and a PhD in Cellular Biology by the University of Zaragoza (Spain). Her thesis was focused on the study of epigenetic regulation of endogenous retroviruses in embryonic stem cells. In 2013 she moved to Icahn School of Medicine at Mount Sinai (New York, USA) where she continued exploring pluripotency from a proteomic perspective, and became interested in studying the interplay of epigenetic regulators with RNA. Recently, she has been appointed principal investigator at the Center for Research in Molecular Medicine and Chronic Diseases (CiMUS, University of Santiago de Compostela, Spain), where she is setting up her laboratory focused on RNA epitranscriptomics in ageing.

KNOW-HOW

Embryonic stem cells

Somatic cell reprogramming

Proteomics

Epigenetics

Epitranscriptomics

KEY PUBLICATIONS

1. Guallar D, Bi X, Pardavila JA, Huang X, Saenz C, Shi X, Zhou H, Faiola F, Ding J, Haruehanroengra P, Yang F, Li D, Sanchez-Priego C, Saunders A, Pan F, Valdes VJ, Kelley K, Blanco MG, Chen L, Wang H, Sheng J, Xu M, Fidalgo M, Shen X, Wang J. (2018). “RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells” Nature Genetics, 50(3):443-451.

2. Saunders A, Huang X, Fidalgo M, Reimer MH, Faiola F, Ding J, Sánchez-Priego C, Guallar D, Saenz C; Li D; Wang J. (2017) “The SIN3a/HDAC corepressor complex functionally cooperates with Nanog to promote pluripotency”. Cell Reports. 18, pp. 1713 – 1726.

3. Fidalgo M, Huang X*, Guallar D*, Sanchez-Priego C, Valdes VJ, Saunders A, Ding J, Wu WS, Clavel C, Wang J. (2016) “Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States” Cell Stem Cell. 19 – (3), pp. 355 – 69.

4. Guallar D, Wang J. (2016) “Taking the RISC of exiting naïve pluripotency”. Genome Biology. 17, pp. 104 – 107.

5. Ding J, Huang X; Shao N, Zhou H, Lee DF, Faiola F, Fidalgo M, Guallar D, Saunders A,  Shliaha PV, Wang H, Waghray A, Papatsenko D,  Sánchez-Priego C, Li D,  Yuan Y, Lemischka IR, Shen L, Kelley K, Deng H, Wang J. (2015) “Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming” Cell Stem Cell. 16- (6), pp. 653 – 668.

6. Gingold J*, Fidalgo M*, Guallar D, Lau Z, Sun Z, Zhou H, Faiola F, Huang X, Lee DF, Waghray A, Schaniel C, Felsenfeld DP, Lemischka IR, Wang J. (2014) “A genome-wide RNAi screen identifies opposing functions of Snai1 and Snai2 on the Nanog dependency in reprogramming” Molecular Cell. 56 – (1), pp. 140 – 152.

7. Guallar D and Wang J. (2014) “RNA-binding proteins in pluripotency, differentiation, and reprogramming”. Frontiers in Biology (Beijing). 9 – 5, pp. 389 – 409.

8. Guallar D, Pérez-Palacios R, Maria Climent; Ignacio Martínez; Ana Larraga; Marta Fernández Juan; Cesar Vallejo; Pedro Muniesa; Jon Schoorlemmer. (2012) “Expression of endogenous retroviruses is negatively regulated by the pluripotency marker Rex1/Zfp42”.Nucleic Acids Research. 40 – 18, pp. 8993 – 9007.

9. Garcia Tuñon I, Guallar D, Alonso Martin S, Benito A, Benítez Lázaro A, Pérez Palacios R, Muniesa P, Climent M, Sánchez M, Vidal MA, Schoorlemmer J. (2011) “Association of Rex-1 to target genes supports its interaction with Polycomb function”. Stem Cell Research. 7 – 1, pp. 1 – 16.

“”

“”