KEYWORDS
RNA
•
RNA editing
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ADAR
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cancer
•
brain
BIO here
PI (RNA Editing laboratory) at the OPBG IRCCS, Rome, Italy.
Specialization in Pathology (Faculty of Medicine), University of Tor Vergata, Rome, Italy.
Post-doc (RNA editing) at the MRC, Human Genetic Unit, Edinburgh, UK.
Post-doc in Neurobiology, CNR, Rome, Italy.
European Fellow (Human Genome Project) at the CNR, Rome Italy.
Degree in Biological Science, University “La Sapienza” Rome, Italy.
Know-How here
The RNA editing has a critical role in superimposing novel/additional genetic information to the
genomically hard-wired transcriptome. The most common type of RNA editing in humans consists in the A-to-I nucleotide conversion within double-stranded RNA molecules catalyzed by the
Adenosine Deaminases that Act on dsRNA (ADARs) family of enzymes.
In our lab we study the impact of the ADAR enzymes in mammalian brain and their role in neuronal cells transformation.
Key publications here
(*) corresponding
Silvestris DA, Picardi E, Cesarini V, Fosso B, Mangraviti N, Massimi L, Martini M, Pesole G, Locatelli F, Gallo A.*
Genome Biol. 2019 Feb 13;20(1):33. doi: 10.1186/s13059-019-1647-x.
Cesarini V, Silvestris DA, Tassinari V, Tomaselli S, Alon S, Eisenberg E, Locatelli F, Gallo A.*
ADAR2/miR-589-3p axis controls glioblastoma cell migration/invasion.
Nucleic Acids Res. 2018 Feb 28;46(4):2045-2059. doi: 10.1093/nar/gkx1257.
Tomaselli S, Galeano F, Alon S, Raho S, Galardi S, Polito V, Presutti C, Vincenti S, Eisenberg E, Locatelli F, Gallo A*
Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma. Genome Biol. 2015 Jan 13;16(1):5.
Alon S, Mor E, Vigneault F, Church GM, Locatelli F, Galeano F, Gallo A*, Shomron N, Eisenberg E. Systematic identification of edited microRNAs in the human brain.
Genome Res. 2012 Aug;22(8):1533-40.
Galeano F, Rossetti C, Tomaselli S, Cifaldi L, Lezzerini M, Pezzullo M, Boldrini R, Massimi L, Di Rocco CM, Locatelli F, Gallo A*
Oncogene. 2013 Feb 21;32(8):998-1009.
Cenci C, Barzotti R, Galeano F, Corbelli S, Rota R, Massimi L, Di Rocco C, O’Connell MA,
Gallo A.*
Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation. JBC 2008 Jan. 4.
An ADAR that edits transcripts encoding ion channel subunits functions as a dimer.
Gallo A, Keegan LP, Ring GM, O’Connell MA.
EMBO J. 2003 Jul 1;22(13):3421-30.
