cap modifications


BIO here


We are interested in the writing and reading of modifications in eukaryote mRNA, with a particular focus on m6A. We primarily work on plants, but also S. cereviciae and through collaborations Drosophila, and mammalian systems.


Key publications here

Růžička K., Zhang M, Campilho A., Bodi Z., Kashif M., Saleh M, Eeckhout D, El-Showk S., Li H., Zhong S., De Jaeger G., Mongan NP., Hejátko J., Helariutta Y., Fray RG. (2017) Identification of Factors Required for m6A mRNA Methylation in Arabidopsis Reveals a Role for the Conserved E3 Ubiquitin Ligase HAKAI. New Phytologist. 215; 157-172.

Haussmann IU., Bodi Z., Sanchezmoran E., Mongan NP., Archer N., Fray RG., Soller M. (2016) m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex

Determination. Nature 540; 301-304       

Bodi Z., Bottley A., Archer N., May ST., Fray RG. (2015) Yeast m(6)A Methylated mRNAs Are Enriched on Translating Ribosomes during Meiosis, and under Rapamycin Treatment. PLOS ONE 10  Issue: 7 Article Number: e0132090.

Bodi Z., Zhong S., Mehra S., Song J., Graham N., Li H., May S. and Fray RG., 2012. Adenosine methylation in Arabidopsis mRNA is associated with the 3′ end and reduced levels cause developmental defects. Frontiers in Plant Science | Plant Genetics and Genomics: Front. Plant Sci. 3:48

Kruse S, Zhong S, Bodi Z, et al. A novel synthesis and detection method for cap-associated adenosine modifications in mouse mRNA. Scientific Reports. 2011;1:126. doi:10.1038/srep00126.

Bodi Z., Button JD., Grierson D, Fray RG. (2010) Yeast targets for mRNA methylation. Nucleic Acids Res 38(16), 5327-35

Zhong S, Li H, Bodi Z, Button J, Vespa L, Herzog M. and Fray R (2008) MTA encodes an Arabidopsis mRNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor. The Plant Cell, 20: 1278-1288.