KEYWORDS
tRNA modification
•
Dnmt2
•
Queuosine
•
RNA methylation
•
5-methyl-cytosine
Education:
Studies of Biology and Biochemistry, ETH Zürich (Switzerland)
1994 – 1997 Postdoc with Jasper Rine, University of California, Berkeley
1997 – 2004 Independent Group Leader, Max-Planck-Insitute for Molecular Genetics, Berlin
2004 – 2005 Professor of Genetics, Justus-Liebig-Universität Gießen
2005 – 2013 Professor of Genetics, Universität Duisburg-Essen
since 2013 Professor of Molecular Cell Biology, Humboldt-Universität zu Berlin
Molecular genetics of S. pombeand S. cerevisiae
RNA bisulfite sequencing
Molecular biology
Biochemistry
RNA methylation
Gene Silencing
Heterochromatin
Tuorto F, Legrand C, Cirzi C, Federico G, Liebers R, Müller M, Ehrenhofer-Murray AE, Dittmar G, Gröne HJ, Lyko F. (2018) Queuosine-modified tRNAs confer nutritional control of protein translation. EMBO J. 2018 Sep 14;37(18).
Müller M, Hartmann M, Schuster I, Bender S, Thüring KL, Helm M, Katze JR, Nellen W, Lyko F, Ehrenhofer-Murray AE. Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine. Nucleic Acids Res. 2015 Dec 15;43(22):10952-62.
Becker M, Müller S, Nellen W, Jurkowski TP, Jeltsch A, Ehrenhofer-MurrayAE. (2012) Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling. Nucleic Acids Res. 2012;40(22):11648-58.
Jeltsch A, Ehrenhofer-Murray A, Jurkowski TP, Lyko F, Reuter G, Ankri S, Nellen W, Schaefer M, Helm M. (2017) Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation. RNA Biol.2017 Sep 2;14(9):1108-1123.
Anedchenko EA, Samel-Pommerencke A, Tran Nguyen TM, Shahnejat-Bushehri S, Pöpsel J, Lauster D, Herrmann A, Rappsilber J, Cuomo A, Bonaldi T, Ehrenhofer-Murray AE. (2019) The kinetochore module Okp1CENP-Q/Ame1CENP-U is a reader for N-terminal modifications on the centromeric histone Cse4CENP-A. EMBO J.2019 Jan 3;38(1).
Samel A., Cuomo A., Bonaldi T., A. E. Ehrenhofer-Murray. (2012) Methylation of CenH3 arginine 37 regulates kinetochore integrity and chromosome segregation. PNAS109(23):9029-34
Ehrentraut S, Weber JM, Dybowski JN, Hoffmann D,Ehrenhofer-MurrayAE (2010) Rpd3-dependent boundary formation at telomeres by removal of Sir2 substrate. PNAS. 2010 Mar 23;107(12):5522-7.
Irlbacher H, Franke J, Manke T, Vingron M, Ehrenhofer-MurrayAE (2005) Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiaeby a regulator of meiotic gene expression.Genes Dev. 2005 Aug 1;19(15):1811-22.
Meijsing SH, Ehrenhofer-MurrayAE. (2001) The silencing complex SAS-I links histone acetylation to the assembly of repressed chromatin by CAF-I and Asf1 inSaccharomyces cerevisiae. Genes Dev. 2001 Dec 1;15(23):3169-82.
