KEYWORDS

tRNA modification

Dnmt2

Queuosine

RNA methylation

5-methyl-cytosine

BIO

Education: 

Studies of Biology and Biochemistry, ETH Zürich (Switzerland)

 

1994 – 1997 Postdoc with Jasper Rine, University of California, Berkeley

1997 – 2004 Independent Group Leader, Max-Planck-Insitute for Molecular Genetics, Berlin

2004 – 2005 Professor of Genetics, Justus-Liebig-Universität Gießen

2005 – 2013 Professor of Genetics, Universität Duisburg-Essen

since 2013 Professor of Molecular Cell Biology, Humboldt-Universität zu Berlin

KNOW-HOW

Molecular genetics of S. pombeand S. cerevisiae

RNA bisulfite sequencing

Molecular biology

Biochemistry

RNA methylation

Gene Silencing

Heterochromatin

KEY PUBLICATIONS

Tuorto F, Legrand C, Cirzi C, Federico G, Liebers R, Müller M, Ehrenhofer-Murray AE, Dittmar G, Gröne HJ, Lyko F. (2018) Queuosine-modified tRNAs confer nutritional control of protein translationEMBO J. 2018 Sep 14;37(18).

Müller M, Hartmann M, Schuster I, Bender S, Thüring KL, Helm M, Katze JR, Nellen W, Lyko F, Ehrenhofer-Murray AE. Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuineNucleic Acids Res. 2015 Dec 15;43(22):10952-62.

Becker M, Müller S, Nellen W, Jurkowski TP, Jeltsch A, Ehrenhofer-MurrayAE. (2012) Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signalingNucleic Acids Res. 2012;40(22):11648-58. 

Jeltsch A, Ehrenhofer-Murray A, Jurkowski TP, Lyko F, Reuter G, Ankri S, Nellen W, Schaefer M, Helm M. (2017) Mechanism and biological role of Dnmt2 in Nucleic Acid MethylationRNA Biol.2017 Sep 2;14(9):1108-1123.

Anedchenko EA, Samel-Pommerencke A, Tran Nguyen TM, Shahnejat-Bushehri S, Pöpsel J, Lauster D, Herrmann A, Rappsilber J, Cuomo A, Bonaldi T, Ehrenhofer-Murray AE. (2019) The kinetochore module Okp1CENP-Q/Ame1CENP-U is a reader for N-terminal modifications on the centromeric histone Cse4CENP-AEMBO J.2019 Jan 3;38(1).

Samel A., Cuomo A., Bonaldi T., A. E. Ehrenhofer-Murray. (2012) Methylation of CenH3 arginine 37 regulates kinetochore integrity and chromosome segregation. PNAS109(23):9029-34

Ehrentraut S, Weber JM, Dybowski JN, Hoffmann D,Ehrenhofer-MurrayAE (2010) Rpd3-dependent boundary formation at telomeres by removal of Sir2 substratePNAS. 2010 Mar 23;107(12):5522-7.

Irlbacher H, Franke J, Manke T, Vingron M, Ehrenhofer-MurrayAE (2005) Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiaeby a regulator of meiotic gene expression.Genes Dev. 2005 Aug 1;19(15):1811-22.

Meijsing SH, Ehrenhofer-MurrayAE. (2001) The silencing complex SAS-I links histone acetylation to the assembly of repressed chromatin by CAF-I and Asf1 inSaccharomyces cerevisiaeGenes Dev. 2001 Dec 1;15(23):3169-82.

 

“”

“”