Dr. Alberto Dávalos , BSc, MBA, PhD, holds a degree in Pharmacy and Biochemistry by San Marcos University (Lima) and a PhD in Pharmacy by Universidad Complutense de Madrid (Madrid). He has conducted postdoctoral research at the Hospital Ramón y Cajal (Madrid ), at Yale University School of Medicine, (New Haven), and at New York University School of Medicine (New York).
Dr. Dávalos´s research program focuses in identifying and characterizing new noncoding RNAs (miRNAs, lncRNAs and other type of regulatory RNAs) that regulate lipid metabolism and the effects of minor dietary components (micronutrients) on their expression. His experimental approaches include human intervention studies, animals model studies, ex vivo studies and different organoids and cell culture studies. Noncoding RNAs have been recognized as critical modulators of cardiovascular system in health and disease. He hopes to: (i) identify new therapeutic strategies through modulating noncoding RNAs levels by the diet or other lifestyle factors to treat cardiometabolic diseases; (ii) understand lifestyle modification of the epigenome and personalize the health of individuals using epigenetics (particularly noncoding RNAs) for the development of Precision Nutrition; and (iii) to identify novel approaches and mechanisms based on miRNAs (i.e. transported in exosomes) to regulate the gut microbiota or for cross-kingdom regulation.
Dietary supplementation with hybrid palm oil alters liver function in the common Marmoset. Spreafico F, Sales RC, Gil-Zamorano J, Medeiros PDC, Latasa MJ, Lima MR, de Souza SAL, Martin-Hernández R, Gómez-Coronado D, Iglesias-Gutierrez E, Mantilla-Escalante DC, das Graças Tavares do Carmo M, Dávalos A. Sci Rep. 2018 Feb 9;8(1):2765.
Modulation of miRNA expression in aged rat hippocampus by buttermilk and krill oil.Crespo MC, Tomé-Carneiro J, Gómez-Coronado D, Burgos-Ramos E, García-Serrano A, Martín-Hernández R, Baliyan S, Fontecha J, Venero C, Dávalos A, Visioli F. Sci Rep. 2018 Mar 5;8(1):3993.
Breast milk microRNAs harsh journey towards potential effects in infant development and maturation. Lipid encapsulation can help. Tomé-Carneiro J, Fernández-Alonso N, Tomás-Zapico C, Visioli F, Iglesias-Gutierrez E, Dávalos A. Pharmacol Res. 2018 Jun;132:21-32.
Circulating microRNAs as emerging cardiac biomarkers responsive to acute exercise. de Gonzalo-Calvo D, Dávalos A, Fernández-Sanjurjo M, Amado-Rodríguez L, Díaz-Coto S, Tomás-Zapico C, Montero A, García-González Á, Llorente-Cortés V, Heras ME, Boraita Pérez A, Díaz-Martínez ÁE, Úbeda N, Iglesias-Gutiérrez E. Int J Cardiol. 2018 Aug 1;264:130-136.
Hydroxytyrosol supplementation modulates the expression of miRNAs in rodents and in humans. Tomé-Carneiro J, Crespo MC, Iglesias-Gutierrez E, Martín R, Gil-Zamorano J, Tomas-Zapico C, Burgos-Ramos E, Correa C, Gómez-Coronado D, Lasunción MA, Herrera E, Visioli F, Dávalos A. J Nutr Biochem. 2016 Aug;34:146-55.