KEYWORDS
2´O-methylation (Nm)
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small non-coding RNA
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gene regulation
EDUCATION
2019 co-group leader of the TErBio lab IBPS – Paris, France
2015 HDR (Habilitation) – Sorbonne Université –
2016 co-group leader of the GED lab IBPS – Paris, France
2006 PhD, Biology, Genetics – Pasteur Institute Paris, France
2003 MSc, Biology, Genetics – Jacques Monod Institute, Paris, France
RESEARCH INTERESTS & ONGOING COLLABORATIONS
sncRNAs, RNA methylation, Epitranscriptomic, chromatin, RNAPII biogenesis. Pr. Yuri Motorin, University of Lorraine, Nancy; Pr. Josef Gecz – Australia, Child Hospital of Adelaide; Dr. Matthias Schaefer, MFPL, Vienna; Dr. Jean-Yves Roignant, IMB, Mainz; Dr. Damien Brégeon, IBPS-B2A, Paris & D. Guérineau, ICSN Gif/Yvette.
RESEARCH EXPERIENCE
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Institut de Biologie Paris Seine – January 2019 co-group leader of TERbio team: Transgenerational Epigenetics and small RNA biology (HCERES evaluated wave D Dec 2017)
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Institut de Biologie Paris Seine (IBPS). Since 2016: co-group leader of the Genetics & Epigenetics of Drosophila Laboratory. IBPS, Paris. Since Sept 2013: Associate Professor – Sorbonne University. IBPS.
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IBPS, France. Sept 2011-Oct 2013: ANR Postdoctoral fellow. Dr. Antoniewski lab.
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Wistar Institute of Philadelphia, 2009-2011 & Centre for Genomic Regulation, Barcelona 2007-2009: Postdoctoral fellow. Pr. Shiekhattar lab.
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IRB-Barcelona, Oct 2006-May 2007: Short term Postdoctoral fellow, Pr. Azorin lab.
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Pasteur Institute, Pierre et MArie Curie University (now Sorbonne University) Paris. France. 2002-2006; PhD in Genetics.
Fly Genetics
small RNA biochemestry (RIP, IP, NB, WB, qPCR, RNAseq)
cell culture (Flies and Human)
– van den Beek M, da Silva B, Pouch J, Ali Chaouche MEA, Carré C*, Antoniewski C*. Dual-layer transposon repression in heads of Drosophila melanogaster. RNA. 2018 Sep 14. pii: rna.067173.118. doi: 10.1261/rna.067173.118 – also deposited at bioRxiv: doi: https://doi.org/10.1101/267039.
– M. Angelova; D. Dimitrova; N. Dinges, T. Lence; L. Worpenberg; C. Carré* and JY. Roignant*. (2018) The emerging field of epitranscriptomics in neurodevelopmental and neuronal disorders. Front Bioeng Biotechnol. 2018 Apr 13;6:46. doi: 10.3389/fbioe.2018.00046. eCollection 2018.
– Genenncher B, Durdevic Z, Hanna K, Zinkl D, Mobin MB, Senturk N, Da Silva B, Legrand C, Carré C, Lyko F, Schaefer M. Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats. Cell Rep. 2018 Feb 13;22(7):1861-1874. doi: 10.1016/j.celrep.2018.01.061
– Christophe Antoniewski, Clément Carré*. New rules for regulation of genes by piRNAs in C. elegans. Non-coding RNA Investig 2018. doi: 10.21037/ncri.2018.06.01
– Positioning Europe for the EPITRANSCRIPTOMICS challenge. RNA Biol. 2018 Apr RNA Biol. 2018 May 9:1-3. doi: 10.1080/15476286.2018.1460996 – white paper –
– van den Beek. M, Antoniewski. C, Carré. C* (2014) Isolation of Small Interfering RNAs Using Viral Suppressors of RNA Interference. Methods Mol Biol 1173:147-55.
– Carré. C, Jacquier. C & Antoniewski. C et al (2013) AutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarity. PLoSone. 8(9):e74296.
– Graindorge. A, Carré. C, Gebauer. F (2013) Sex-lethal promotes nuclear retention of msl2 mRNA via interactions with the STAR protein HOW. Genes Dev 27(12):1421-33
Carré C*, Shiekhattar R*. Human GTPases associate with RNA polymerase II to mediate its nuclear import. Mol Cell Biol. 2011 Oct;31(19):3953-62. doi: 10.1128/MCB.05442-11. 2011 Jul 18.
Lloret-Llinares M, Carré C, Vaquero A, de Olano N, Azorín F. Characterization of Drosophila melanogaster JmjC+N histone demethylases. Nucleic Acids Res. 2008 May;36(9):2852-63. doi: 10.1093/nar/gkn098.
