KEYWORDS
Cell physiology
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Molecular mechanism of disease
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Clinical biology
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Molecular biology
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Medical genetics
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Genetics transcription
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Genetics expresión of regulations
Fernando Cardona Díaz is currently co-leader at Molecular and Cellular Endocrinology group in IBIMA (Biomedical Research Institute of Malaga), charge that occupies since 2010. His research group is focused on molecular biology of metabolic diseases, group formally recognized by Innovation Ministry of Andalussian Goverment (CTS981) since 2013. Since 2006, he has been developing his scientific career thanks to public and competitive grants like Juan de la Cierva program (2006-08), Miguel Servet type I (2008-13), Miguel Servet type II (2014-16) program of ISCIII and currently since 2017 inside the Nicolas Monarde program (C-0032-2016). He participates as adscript researcher in the research network CIBER-OBN, (CB06/03/0018) from the Instituto de Salud Carlos III (ISCIII) (Spain) and Cost Action Epitrans (CA16120) from European Cooperation. He has participated as spokesperson in the subcommittee of research at Virgen de la Victoria hospital. He has participated in 15 national and regional public research grants, which 5 of them he has managed as principal investigator. He has obtained concatenated funding from ISCIII competitive research programs in the last 12 years (PI081655,PI11/02518, PI14/00082;PI17/01104). The aim of these projects has been the study of putative mechanism underlying obesity and obesity related-diseases, two of them dealing with gut microbiota and metabolic endotoxemia. He went for a research training stay to Sant Franciscus Gasthuis Hospital Rotterdam (Rotterdam, The Netherlands), where he spent 6 months financed by Jose Castillejo mobility program from Education Ministry (CAS12/00076)(2013). He is author in 84 indexed articles with a total H index of 21 and 1463 citations. In the last five years he has published 27 articles, 9 of them as main author (last or corresponding author, 3 in D1 position, and 6 en Q1, with a total impact factor of 100. He is also author of 1 book, 4 chapter books, and has participated in more than 100 communications in international and national congresses. He managed a thesis work about obesity and obesity-related disease, and actually he is supervisor of four thesis Mora Murri, Mercedes Clemente and Isabel Cornejo. His research work is focused on the study of lipid metabolic disorders: Postprandial Lipidemia. Study of the physiopathology of postprandial hyperlipidemia and lipid metabolism according to metabolic syndrome and obesity. This line is financed by the project PI325/2008 of Health Regional Ministry of Andalusia and by the project PI17/01104 & PI14/00082 of ISCIIII, and has produced the patent ES2370528, P201531945, P201531946. Genetic of obesity and Metabolic Syndrome. This line, related with the previous one, aim to study genetic mutations and signs in patients with extreme phenotypes characterized by unusual gene expression of genes related to lipid metabolism. This line is supported by the project associated to the Miguel Servet Grant CP07/00095 (ISCIII) and by the project PI11/02518 of ISCIII. Study of factors involved in insulin-resistance in obese subjects. This line has as main goals to study the role of adipose tissue over factors in insulin-resistance (Project PI08/1655, ISCIII), and study the role of adipose tissue in insulin-resistance genesis (PI08/1655, ISCIII). Another goal is the study of inflammatory and oxidative stress sings in subjects according to obesity and metabolic syndrome, and the search of new signs associated to obesity and metabolic syndrome.
Know-How here
1: Royo JL, Castellano-Castillo D, Ruiz-Galdon M, Molina-Vega M, Cardona F, Tinahones FJ, Fernández-García JC, Reyes-Engel A. Monoamino oxidase alleles correlate with the presence of essential hypertension among hypogonadic patients. Mol Genet Genomic Med. 2019 Nov 19:e1040. doi: 10.1002/mgg3.1040. [Epub ahead of print] PubMed PMID: 31743621. 2: Ocaña-Wilhelmi L, Cardona F, Garrido-Sanchez L, Fernandez-Garcia D, Tinahones FJ, Ramos-Molina B. Change in serum polyamine metabolome pattern after bariatric surgery in obese patients with metabolic syndrome. Surg Obes Relat Dis. 2019 Nov 2. pii: S1550-7289(19)31078-0. doi: 10.1016/j.soard.2019.10.024. [Epub ahead of print] PubMed PMID: 31813775. 3: Boughanem H, Cabrera-Mulero A, Millán-Gómez M, Garrido-Sánchez L, Cardona F, Tinahones FJ, Moreno-Santos I, Macías-González M. Transcriptional Analysis of FOXO1, C/EBP-α and PPAR-γ2 Genes and Their Association with Obesity-Related Insulin Resistance. Genes (Basel). 2019 Sep 12;10(9). pii: E706. doi: 10.3390/genes10090706. PubMed PMID: 31547433; PubMed Central PMCID: PMC6770962. 4: Castellano-Castillo D, Royo JL, Martínez-Escribano A, Sánchez-Alcoholado L, Molina-Vega M, Queipo-Ortuño MI, Ruiz-Galdon M, J Álvarez-Millán J, Cabezas-Sanchez P, Reyes-Engel A, Tinahones FJ, Cardona F, Fernandez-Garcia JC. Effects of SHBG rs1799941 Polymorphism on Free Testosterone Levels and Hypogonadism Risk in Young Non-Diabetic Obese Males. J Clin Med. 2019 Jul 31;8(8). pii: E1136. doi: 10.3390/jcm8081136. PubMed PMID: 31370189; PubMed Central PMCID: PMC6722847. 5: Mantilla-Escalante DC, López de Las Hazas MC, Gil-Zamorano J, Del Pozo-Acebo L, Crespo MC, Martín-Hernández R, Del Saz A, Tomé-Carneiro J, Cardona F, Cornejo-Pareja I, García-Ruiz A, Briand O, Lasunción MA, Visioli F, Dávalos A. Postprandial Circulating miRNAs in Response to a Dietary Fat Challenge. Nutrients. 2019 Jun 13;11(6). pii: E1326. doi: 10.3390/nu11061326. PubMed PMID: 31200481; PubMed Central PMCID: PMC6627817. 6: Castellano-Castillo D, Denechaud PD, Fajas L, Moreno-Indias I, Oliva-Olivera W, Tinahones F, Queipo-Ortuño MI, Cardona F. Human adipose tissue H3K4me3 histone mark in adipogenic, lipid metabolism and inflammatory genes is positively associated with BMI and HOMA-IR. PLoS One. 2019 Apr 8;14(4):e0215083. doi: 10.1371/journal.pone.0215083. eCollection 2019. PubMed PMID: 30958852; PubMed Central PMCID: PMC6453466. 7: Cornejo-Pareja I, Martín-Núñez GM, Roca-Rodríguez MM, Cardona F, Coin-Aragüez L, Sánchez-Alcoholado L, Gutiérrez-Repiso C, Muñoz-Garach A, Fernández-García JC, Moreno-Indias I, Tinahones FJ. H. pylori Eradication Treatment Alters Gut Microbiota and GLP-1 Secretion in Humans. J Clin Med. 2019 Apr 4;8(4). pii: E451. doi: 10.3390/jcm8040451. PubMed PMID: 30987326; PubMed Central PMCID: PMC6517938. 8: Martín-Núñez GM, Cornejo-Pareja I, Coin-Aragüez L, Roca-Rodríguez MDM, Muñoz-Garach A, Clemente-Postigo M, Cardona F, Moreno-Indias I, Tinahones FJ. H. pylori eradication with antibiotic treatment causes changes in glucose homeostasis related to modifications in the gut microbiota. PLoS One. 2019 Mar 14;14(3):e0213548. doi: 10.1371/journal.pone.0213548. eCollection 2019. PubMed PMID: 30870471; PubMed Central PMCID: PMC6417676. 9: Ramos-Molina B, Castellano-Castillo D, Pastor O, Ocaña-Wilhelmi L, Fernández-García D, Romero-Gómez M, Cardona F, Tinahones FJ. A Pilot Study of Serum Sphingomyelin Dynamics in Subjects with Severe Obesity and Non-alcoholic Steatohepatitis after Sleeve Gastrectomy. Obes Surg. 2019 Mar;29(3):983-989. doi: 10.1007/s11695-018-3612-2. PubMed PMID: 30488259. 10: Castellano-Castillo D, Moreno-Indias I, Sanchez-Alcoholado L, Ramos-Molina B, Alcaide-Torres J, Morcillo S, Ocaña-Wilhelmi L, Tinahones F, Queipo-Ortuño MI, Cardona F. Altered Adipose Tissue DNA Methylation Status in Metabolic Syndrome: Relationships Between Global DNA Methylation and Specific Methylation at Adipogenic, Lipid Metabolism and Inflammatory Candidate Genes and Metabolic Variables. J Clin Med. 2019 Jan 13;8(1). pii: E87. doi: 10.3390/jcm8010087. PubMed PMID: 30642114; PubMed Central PMCID: PMC6352101. 11: Fernandez-Garcia JC, Delpino-Rius A, Samarra I, Castellano-Castillo D, Muñoz-Garach A, Bernal-Lopez MR, Queipo-Ortuño MI, Cardona F, Ramos-Molina B, Tinahones FJ. Type 2 Diabetes Is Associated with a Different Pattern of Serum Polyamines: A Case⁻Control Study from the PREDIMED-Plus Trial. J Clin Med. 2019 Jan 10;8(1). pii: E71. doi: 10.3390/jcm8010071. PubMed PMID: 30634588; PubMed Central PMCID: PMC6352090.
1: Castellano-Castillo D, Moreno-Indias I, Fernandez-Garcia JC, Clemente-Postigo M, Castro-Cabezas M, Tinahones FJ, Queipo-Ortuño MI, Cardona F. Complement Factor C3 Methylation and mRNA Expression Is Associated to BMI and Insulin Resistance in Obesity. Genes (Basel). 2018 Aug 13;9(8). pii: E410. doi: 10.3390/genes9080410.
PubMed PMID: 30104553; PubMed Central PMCID: PMC6116013.
2: Ramos-Molina B, Castellano-Castillo D, Alcaide-Torres J, Pastor Ó, de Luna Díaz R, Salas-Salvadó J, López-Moreno J, Fernández-García JC, Macías-González M, Cardona F, Tinahones FJ. Differential effects of restrictive and malabsorptive bariatric surgery procedures on the serum lipidome in obese subjects. J Clin Lipidol. 2018 Jul 25. pii: S1933-2874(18)30307-6. doi:10.1016/j.jacl.2018.07.006. [Epub ahead of print] PubMed PMID: 30143432.Corresponding Author Fernando Cardona
3: Castellano-Castillo D, Denechaud PD, Moreno-Indias I, Tinahones FJ, Fajas L Queipo-Ortuño MI, Cardona F.Chromatin Immunoprecipitation improvements for the processing of small frozen pieces of Adipose Tissue. Plos One. Manuscript accepted, 2018. Q1 IF: 2,80
4: Castellano-Castillo D, Moreno-Indias I, Fernández-García JC, Alcaide-Torres J, Moreno-Santos I, Ocaña L, Gluckman E, Tinahones F, Queipo-Ortuño MI, Cardona F. Adipose Tissue LPL Methylation is Associated with Triglyceride Concentrations in the Metabolic Syndrome. Clin Chem. 2017 Oct 18. pii: clinchem.2017.277921. doi:10.1373/clinchem.2017.277921. [Epub ahead of print] PubMed PMID: 29046332.IF: 8.08 D1
5: Moreno-Indias I, Tinahones FJ, Clemente-Postigo M, Castellano-Castillo D,Fernández-García JC, Macias-Gonzalez M, Queipo-Ortuño MI, Cardona F. Molecular effect of fenofibrate on PBMC gene transcription related to lipid metabolism in patients with metabolic syndrome. Clin Endocrinol (Oxf). 2017 Mar 2. doi:10.1111/cen.13320. [Epub ahead of print] PubMed PMID: 28251701.IF: 3,32 Q2
6: Moreno-Santos I, Pérez-Belmonte LM, Macías-González M, Mataró MJ, Castellano D, López-Garrido M, Porras-Martín C, Sánchez-Fernández PL, Gómez-Doblas JJ, Cardona F, de Teresa-Galván E, Jiménez-Navarro M. Type 2 diabetes is associated with decreased PGC1αexpression in epicardial adipose tissue of patients with coronary artery disease. J Transl Med. 2016 Aug 19;14(1):243. doi: 10.1186/s12967-016-0999-1. PubMed PMID: 27542888; PubMed Central PMCID:PMC4992233.
Corresponding Author Cardona F Q1 IF:3,78
7: Moreno-Indias I, Sánchez-Alcoholado L, Pérez-Martínez P, Andrés-Lacueva C, Cardona F, Tinahones F, Queipo-Ortuño MI. Red wine polyphenols modulate fecal microbiota and reduce markers of the metabolic syndrome in obese patients. Food Funct. 2016 Apr 20;7(4):1775-87. Corresponding Author Cardona F Q1 IF:3,24
8: Moreno-Indias I, CardonaF, Tinahones FJ, Queipo-Ortuño MI. Impact of the gut microbiota on the development of obesity and type 2 diabetes mellitus. Front Microbiol. 2014 Apr 29;5:190. doi: 10.3389/fmicb.2014.00190. eCollection 2014. Corresponding Author Fernando Cardona Q1 IF:4,076
9: Moreno-Indias I, Torres M, Montserrat JM, Sanchez-Alcoholado L, Cardona F, Tinahones FJ, Gozal D, Poroyko VA, Navajas D, Queipo-Ortuño MI, Farré R. Intermittent hypoxia alters gut microbiota diversity in a mouse model of sleep apnoea. Eur Respir J. 2015 Apr;45(4):1055-65.
IF: 8.08 D1
10: CardonaF, Andrés-Lacueva C, Tulipani S, Tinahones FJ, Queipo-Ortuño MI. Benefits of polyphenols on gut microbiota and implications in human health. J Nutr Biochem. 2013 Aug;24(8):1415-22. doi: 10.1016/j.jnutbio.2013.05.001.Corresponding Author Fernando Cardona IF: 4.552 Q1
11: Tinahones FJ, Queipo-Ortuño MI, Clemente-Postigo M, Fernnadez-Garcia D, Mingrone G, CardonaF. Postprandial hypertriglyceridemia predicts improvement in insulin resistance in obese patients after bariatric surgery. Surg Obes Relat Dis. 2013 Mar-Apr;9(2):213-8. doi: 10.1016/j.soard.2011.08.022.Corresponding Author Fernando Cardona IF: 4,49 D1
