EPITRAN COST Action CA16120 aims at building a synergistic network of researchers actively working on all aspects of epitranscriptomics, thus assembling a critical mass to effectively address the key questions and compete with non-European groups in the field. Extensive collaboration on these questions will foster the creation of a high-impact European research hub on epitranscriptomics, able to drive discovery and indicate future avenues to be pursued. Furthermore, the Action will aid the incorporation of the European biomedical industry in this process, facilitating the translation of discoveries into applications for health-improvement.